This antibody is predicted to react with mouse and rat based on sequence homology.
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: AES-1, AES-2, ESP1, GRG, GRG5, TLE5, amino enhancer of split; Amino enhancer of split; Amino-terminal enhancer of split; Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; TLE family member 5; TLE family member 5, transcriptional modulator
Gene Aliases: AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5; TLE5
UniProt ID: (Human) Q08117
Entrez Gene ID: (Human) 166