PA5-19481 targets Sortilin in flow cytometry, immunoprecipitation, immunocytochemistry, immunofluorescence, immunohistochemistry (frozen), and Western blot applications and shows reactivity with Human, mouse, Cow, and Rat samples.
The PA5-19481 immunogen is synthetic peptide conjugated to KLH derived from within residues 800 to the C-terminus of Human Sortilin.
PA5-19481 detects Sortilin which has a predicted molecular weight of approximately ~100 kDa.
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 100 kDa NT receptor; Glycoprotein 110; Glycoprotein 95; Gp110; Gp95; Gp95, LDLCQ6, NT3, 100 kDa NT receptor; mNTR3; Neurotensin receptor 3; NT3; NTR3; Sortilin
Gene Aliases: 2900053A11Rik; AI852375; Gp95; LDLCQ6; NT3; NTR3; Nts3; Ntsr3; SORT1