This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated. View Details
Heat mediated antigen retrieval recommended prior to tissue staining.
This antibody is predicted to react with chicken and cow based on sequence homology.
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal) L homeolog; cadherin 2, type 1, N-cadherin a (neuronal); Cadherin-2; Cadherin-2A; calcium-dependent adhesion protein, neuronal; CD325; CDHN; CDw325; CDw325 antigen; N-cadherin; N-cadherin 1; N-cadherin A; N-cadherin-2; NCAD; Neural cadherin; Neural cadherin A; Neural cadherin-2
Gene Aliases: cadherin-2; CD325; CDH2; cdh2-a; cdh2-b; cdh2a; CDHN; cdhn-a; CDw325; N-Cad; N-cadherin; NCAD; XELAEV_18031953mg
Molecular Function: cadherin