A suggested positive control is human uterus tissue lysate.
PA5-20245 can be used with blocking peptide PEP-0364.
The PA5-20245 immunogen is located within amino acids 230 - 280 of TIM-1.
Predicted molecular ~ 44kD. In Western blot applications, this antibody has been observed to detect a band at: 60kD (Post-modification: 4 N-linked glycosylation)
Predicted species reactivity based on immunogen sequence: Mouse: (50%), Rat: (44%)
CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.
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Protein Aliases: CD365; HAVcr-1; Hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIMD-1
Gene Aliases: CD365; HAVCR; HAVCR-1; HAVCR1; KIM-1; KIM1; TIM; TIM-1; TIM1; TIMD-1; TIMD1
UniProt ID: (Human) Q96D42
Entrez Gene ID: (Human) 26762