Despite its predicted molecular weight, Aven often migrates at 55kDa in SDS-PAGE. A suggested positive control is Raji cell lysate.\r
PA5-20287 can be used with blocking peptide PEP-0405.
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
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Protein Aliases: apoptosis, caspase activation inhibitor; Cell death regulator Aven; programmed cell death 12
Gene Aliases: 1700013A01Rik; 1700056A21Rik; AVEN; mAven-L; mAven-S; PDCD12