A suggested positive control is A-20 cell lysate.
PA5-20504 can be used with blocking peptide PEP-0624.
TMC6 interacts with, and forms a complex with the zinc transporter 1, SLC30A1, and localizes to the endoplasmic reticulum, nuclear membrane and Golgi apparatus. The inactivation of the TMC6 gene has been implicated in the skin disorder epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. TMC6 encodes integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
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Protein Aliases: epidermodysplasia verruciformis 1; Epidermodysplasia verruciformis protein 1; expressed in activated T/LAK lymphocytes; Protein LAK-4; Transmembrane channel-like protein 6
Gene Aliases: D11Ertd204e; EV1; EVER1; EVIN1; LAK-4P; TMC6