A suggested positive control is SK-N-SH cell lysate.
PA5-20843 can be used with blocking peptide PEP-0957.
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
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Protein Aliases: Down-regulated by v-SRC; DRS; DRS protein; DRS, ETX1, SRPX1; epididymis secretory sperm binding protein Li 83p; Sushi repeat-containing protein SRPX; sushi-repeat containing protein, X-linked; Sushi-repeat-containing protein SRPX; sushi-repeat-containing protein X chromosome; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome; sushi-repeat-containing protein, X-linked
Gene Aliases: DRS; drs-1; drs-2; ETX1; HEL-S-83p; mDRS-1; mDRS-2; SRPX; SRPX1