A suggested positive control is K562 cell lysate.\r
PA5-20996 can be used with blocking peptide PEP-1110.
ATP11B is a widely expressed integral membrane ATPase and is thought to drive the transport of phospholipids across membranes. It has been suggested that ATP11B is hormonally regulated and plays a role in the subnuclear trafficking of transcription factors with RING motifs. While the exact molecule ATP11B transports is unknown, increased mRNA expression of the homologous ATP11A has been observed in cells resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs), suggesting that ATP11B may also play a role in cell survival under harsh conditions.
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Protein Aliases: ATPase class VI type 11B; ATPase IR; ATPase, class VI, type 11B; P4-ATPase flippase complex alpha subunit ATP11B; Phospholipid-transporting ATPase IF; probable phospholipid-transporting ATPase IF; TIEG; TIEG1; truncated ATPase 11B protein
Gene Aliases: 1110019I14Rik; ATP11B; ATPIF; ATPIR; KIAA0956; mKIAA0956