A suggested positive control is rat brain tissue lysate.
PA5-21038 can be used with blocking peptide PEP-1152.
STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.
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Protein Aliases: Double-stranded RNA-binding protein Staufen homolog 1; protein phosphatase 1, regulatory subunit 150; RP3-470L14.2; staufen RNA binding protein homolog 1; staufen, RNA binding protein, homolog 1
Gene Aliases: 5830401L18Rik; AW549911; C85792; PPP1R150; STAU; STAU1