A suggested positive control is A-20 cell lysate.
PA5-21132 can be used with blocking peptide PEP-1246.
ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein and a transcriptional coactivator. ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity and this activity is inhibited by the N-terminus in the full-length ZIMP7. ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhances Androgen Receptor (AR)- mediated transcription. The interaction between ZIMP7 and SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification.
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Protein Aliases: PIAS-like protein Zimp7; Zinc finger MIZ domain-containing protein 2; zinc finger, MIZ-type containing 2
Gene Aliases: D11Bwg0280e; HRIHFB2007; hZIMP7; KIAA1886; NET27; TRAFIP20; ZIMP7; ZMIZ2
Molecular Function: ligase