The G(0)-G(1) switch gene 2 (G0S2) codes for a mitochondrial protein that is important in apoptosis, lipolysis, and triacylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase and decreases the breakdown of lipid droplets. In Crohn's colitis, the presence of G0S2 is increased in correlation to the amount of non-converted lipid in waste. In squamous lung cancer, mutations in the G0S2 gene are common. In breast cancer, epigenetic silencing of G0S2 occurs, and normal apoptotic regulation of aberrant cells is negatively impacted. However, when G0S2 is not epigenetically modified, it is the best mediator of the Bcl-2/Bax heterodimer, resulting in apoptosis of cancerous cells.
Protein Aliases: G0/G1 switch protein 2; G0/G1 switch regulatory protein 2; G0/G1switch 2; Putative lymphocyte G0/G1 switch gene; RP1-28O10.2
Gene Aliases: G0S2
UniProt ID: (Human) P27469
Entrez Gene ID: (Human) 50486