CTSD encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript.
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Protein Aliases: Cathepsin D; ceroid-lipofuscinosis; ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; epididymis secretory sperm binding protein Li 130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; neuronal 10
Gene Aliases: CLN10; CPSD; CTSD; HEL-S-130P
UniProt ID: (Human) P07339
Entrez Gene ID: (Human) 1509