DAZAP2 encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma.
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Protein Aliases: brain-expressed protein; DAZ-associated protein 2; deleted in azoospermia associated protein 2; Deleted in azoospermia-associated protein 2; proline-rich transcript; proline-rich transcript in brain; proline-rich transcript, brain-expressed protein; PRTB
Gene Aliases: DAZAP2; KIAA0058; PRTB
UniProt ID: (Human) Q15038
Entrez Gene ID: (Human) 9802