PA5-27275 targets Granulins in IF, IHC-P and WB applications and shows reactivity with Human and mouse samples.
The PA5-27275 immunogen is recombinant fragment corresponding to a region within amino acids 278 and 585 of Human Granulins.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
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Protein Aliases: Acrogranin; acrogranulin; Epithelin precursor; Epithelin-1; Epithelin-2; Epithelin/granulin precursor; GEP; Glycoprotein of 88 Kda; GP88; Granulin A; Granulin B; Granulin C; Granulin D; Granulin E; Granulin F; Granulin G; Granulin precursor; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; granulin-epithelin; granulins; Paragranulin; PC cell-derived growth factor; PCDGF; PEPI; PGRN; Proepithelin; Progranulin
Gene Aliases: CLN11; epithelin; GEP; GP88; GRN; PCDGF; PEPI; PGRN