Recommended positive controls: HeLa, HeLaS3, HepG2.
Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (84%), Dog (97%), Pig (96%), Rabbit (96%), Chicken (90%), Rhesus Monkey (100%), Bovine (94%), Guinea pig (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
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Protein Aliases: CCR; CPR; CY DKFZp686G04235; DKFZp686G04235; FLJ26468; NADPH Cytochrome; NADPH--cytochrome P450 reductase; NADPH-dependent cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450 Reductase
Gene Aliases: CPR; CYPOR; P450R; POR
UniProt ID: (Human) P16435
Entrez Gene ID: (Human) 5447