PA5-27920 targets ECH1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27920 immunogen is recombinant fragment corresponding to a region within amino acids 34 and 328 of Human ECH1.
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This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
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Protein Aliases: 4)-dienoyl-CoA isomerase; 4-dienoyl-CoA isomerase; 5)-Delta(2; 5-delta2; delta(3; Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; delta3; delta3,5-delta2,4-dienoyl-CoA isomerase; delta3,5-delta2,4-dienoyl-coenzyme A isomerase; dienoyl-CoA isomerase; enoyl CoA hydratase 1, peroxisomal; enoyl Coenzyme A hydratase 1; enoyl Coenzyme A hydratase 1, peroxisomal; enoyl-CoA hydratase 1, peroxisomal; HPXEL; mitochondrial; peroxisomal; peroxisomal enoyl-CoA hydratase 1
Gene Aliases: ECH1; HPXEL
UniProt ID: (Human) Q13011
Entrez Gene ID: (Human) 1891