PA5-29134 targets Cytokeratin 6B in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29134 immunogen is recombinant protein fragment corresponding to a region within amino acids 134 and 564 of Human Cytokeratin 6B.
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The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
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Protein Aliases: 60-kDa keratin; CK-6A; CK-6B; CK-6C; CK-6D; CK-6E; CK6B; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; Cytokeratin-6A; Cytokeratin-6B; Cytokeratin-6C; Cytokeratin-6D; Cytokeratin-6E; epidermal; Hom s 5; K6A; K6B; K6C; kamp-keratin derived antimicrobial peptide; KDAMP; keratin; keratin 6A, , type II; keratin 6A, type II; keratin 6B, type II; keratin 6C, type II; keratin 6E; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6b; keratin complex 2, basic, gene 6c; keratin complex 2, gene 6a; Keratin K6h; keratin, epidermal type II, K6A; keratin, epidermal, type II, K6B; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; Keratin, type II cytoskeletal 6C; Keratin-6-alpha; keratin-6-beta; Keratin-6A; Keratin-6B; Keratin-6C; keratin-like 1 (a type II keratin sequence); KRTL1; mK6-alpha; mK6-beta; type II; type II cytoskeletal 6B; Type-II keratin Kb10; Type-II keratin Kb12; Type-II keratin Kb6
Gene Aliases: 2310016L08Rik; BB144589; CK-6B; CK-6C; CK-6E; CK6A; CK6B; CK6C; CK6D; K6A; K6B; K6C; K6D; K6E; Ker2; Krt2-6; Krt2-6a; Krt2-6b; Krt2-6c; Krt6; KRT6A; KRT6B; KRT6C; KRT6D; KRT6E; KRTL1; mK6[a]; mK6[b]; MK6a; PC2; PC3; PC4; PPKNEFD