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PA5-29918 targets SNF5 in WB applications and shows reactivity with mouse samples.
The PA5-29918 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 208 of Human SNF5.
The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2alpha) and Brg-1 (also designated SNF2beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
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Protein Aliases: BAF47; BRG1-associated factor 47; Integrase interactor 1 protein; mSNF5; SNF5 homolog; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI10; TYE4
Gene Aliases: Baf47; Ini1; Smarcb1; Snf5l1
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