PA5-30102 targets NFYB in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30102 immunogen is recombinant fragment corresponding to a region within amino acids 22 and 207 of Human NFYB.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B subunit; CAAT box DNA-binding protein subunit B; CCAAT-binding transcription factor subunit A; HAP3; NF-YB; Nuclear transcription factor Y subunit B; Nuclear transcription factor Y subunit beta; nuclear transcription factor Y, beta; Transcription factor NF-Y; Transcription factor NF-Y, B subunit
Gene Aliases: CBF-A; CBF-B; HAP3; NF-YB; NFYB
UniProt ID: (Human) P25208
Entrez Gene ID: (Human) 4801