Recommended positive controls: NT2D1, IMR32.\r
Predicted reactivity: Mouse (93%), Rat (93%), Bovine (97%).\r
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calcineurin A gamma; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform; CAM-PRP catalytic subunit; protein phosphatase 2B, catalytic subunit, gamma isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform; protein phosphatase 3, catalytic subunit, gamma isozyme; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Gene Aliases: CALNA3; CNA3; PP2Bgamma; PPP3CC
UniProt ID: (Human) P48454
Entrez Gene ID: (Human) 5533