Recommended positive controls: A549, HeLa, HepG2, HCT116, mouse brain.
Predicted reactivity: Mouse (92%), Rat (91%), Zebrafish (82%), Pig (94%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
A steady-state level of amyloid beta-peptide (Abeta) represents a balance between its biosynthesis from the amyloid precursor protein (APP) through the action of the beta and gamma-secretases and its catabolism by a variety of proteolytic enzymes. Thimet Oligopeptidase (THOP1) has been shown to promote A-beta degradation. It has also been shown to play a role in antigen presentation, metabolism of neuropeptides under 20 amino acids, and cytoplasmic peptide degradation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 3.4.24; EC 188.8.131.52; Endopeptidase 24.15; MP78; Thimet oligopeptidase
Gene Aliases: AI131655; AI327041; EP24.15; MEPD_HUMAN; MP78; THOP1; TOP
Molecular Function: metalloprotease