Recommended positive controls: A549, HeLa.
Predicted reactivity: Mouse (89%), Rat (92%), Rabbit (96%), Chicken (88%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
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Protein Aliases: eIF-2-beta; EIF2BA; Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; protein phosphatase 1, regulatory subunit 67
Gene Aliases: eIF-2-beta; EIF2; EIF2B; EIF2beta; EIF2S2; PPP1R67
UniProt ID: (Human) P20042
Entrez Gene ID: (Human) 8894