PA5-30563 targets QK1 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30563 immunogen is recombinant fragment corresponding to a region within amino acids 106 and 341 of Human QK1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]). QKI proteins regulate RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability (Lauriat et al., 2008 [PubMed 17918747]).
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Protein Aliases: homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; hqkI; KH domain RNA binding; lethal, Chr 17, U Wisconsin 1; MqkI; Protein quaking; QK; QK1; QK3; QKI, KH domain containing, RNA binding; QKI-5 protein; quaking homolog; quaking homolog, KH domain RNA binding; RNA binding protein HQK
Gene Aliases: 1110003F05Rik; 1500005P18; HKQ; Hqk; hqkI; l(17)-1Wis; l17Wis1; QK; QK1; QK3; Qka1; QKI