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PA5-30688 targets PCK2 in WB applications and shows reactivity with Human samples.
The PA5-30688 immunogen is recombinant fragment corresponding to a region within amino acids 157 and 431 of Human PCK2.
This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described.
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Protein Aliases: HGNC:8725; PEP carboxykinase; PEPCK-M; phosphoenolpyruvate carboxykinase 2 (mitochondrial); Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; phosphopyruvate carboxylase
Gene Aliases: PCK2; PEPCK2
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