Recommended positive controls: DDDDK-tagged HEY1-transfected 293T.
Predicted reactivity: Mouse (96%), Rat (89%), Xenopus laevis (81%), Dog (94%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.
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Protein Aliases: basic helix-loop-helix protein OAF1; BHLHb31; Cardiovascular helix-loop-helix factor 2; CHF-2; CHF2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split-related protein 1; hairy-related transc; Hairy-related transcription factor 1; hairy/enhancer-of-split related with YRPW motif 1; Hairy/enhancer-of-split related with YRPW motif protein 1; HERP2; hes-related family bHLH transcription factor with YRPW motif 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HESR1; hHRT1; HRT-1; OAF1
Gene Aliases: BHLHB31; CHF2; HERP2; HESR1; HEY1; hHRT1; HRT-1; HRT1; OAF1
UniProt ID: (Human) Q9Y5J3
Entrez Gene ID: (Human) 23462