PA5-31123 targets PCDHB16 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-31123 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 286 of Human PCDHB16.
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This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
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Protein Aliases: cadherin ME1; ME1; PCDH-beta-16; PCDH-BETA16; PCDH3X; PCDHB8a; PCDHbeta 16; protocadherin beta 8a; Protocadherin beta-16; Protocadherin-3X
Gene Aliases: KIAA1621; ME1; PCDH-BETA16; PCDH3X; PCDHB16; PCDHB8a
UniProt ID: (Human) Q9NRJ7
Entrez Gene ID: (Human) 57717