Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (84%), Rat (81%), Chimpanzee (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hPreP; Metalloprotease 1; metalloprotease 1 (pitrilysin family); Pitrilysin metalloproteinase 1; PreP peptidasome; Presequence protease, mitochondrial
Gene Aliases: KIAA1104; MP1; PITRM1; PREP
UniProt ID: (Human) Q5JRX3
Entrez Gene ID: (Human) 10531