Recommended positive controls: A549, HeLa, Jurkat, Raji.
Predicted reactivity: Mouse (95%), Rat (94%), Xenopus laevis (80%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: kelch-like family member 21; Kelch-like protein 21; MGC99635
Gene Aliases: KIAA0469; KLHL21
UniProt ID: (Human) Q9UJP4
Entrez Gene ID: (Human) 9903