PA5-31862 targets S100A6 in IF and WB applications and shows reactivity with Human samples.
The PA5-31862 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 90 of Human S100A6.
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The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.
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Protein Aliases: 2A9; CACY; Calcyclin; Growth factor-inducible protein 2A9; MLN 4; PRA; Prolactin receptor-associated protein; Protein S100-A6; S100 calcium-binding protein A6; S100 calcium-binding protein A6 (calcyclin)
Gene Aliases: 2A9; 5B10; CABP; CACY; PRA; S100A6
UniProt ID: (Human) P06703
Entrez Gene ID: (Human) 6277