In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat (100%) Mouse, Bat, Dog, Hamster, Panda, Horse, Pig (94%).
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
Protein Aliases: Brgr1; Brgrb; G-protein coupled receptor 68; GPR12A; OGR-1; ovarian cancer G protein-coupled receptor, 1; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
Gene Aliases: GPR12A; GPR68; OGR1
UniProt ID: (Human) Q15743
Entrez Gene ID: (Human) 8111