In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.\r
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%) Marmoset (95%) Dog, Panda (89%) Mouse, Rat, Elephant, Horse, Rabbit, Pig (84%).
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells.
Protein Aliases: NB4 apoptosis/differentiation related protein; Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1; PTEN-like phosphatase
Gene Aliases: DUSP23; MOSP; PLIP; PNAS-129; PTPMT1
UniProt ID: (Human) Q8WUK0
Entrez Gene ID: (Human) 114971