In IHC applications, antigen retrieval using Proteinase K treatment is recommended.
Percent identity with other species by BLAST analysis: Human (100%) Gorilla, Gibbon, Monkey, Marmoset (95%) Dog (80%).
Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission.
The A2aAR is a glycoprotein that can activate adenylyl cyclase via Gs interactions. Stimulation of A2aAR and the resultant accumulation of cAMP inhibits platelet aggregation and in certain vascular beds is associated with vasodilation and drop in blood pressure. A2aAR is reported to interact with D2 dopamine receptor sites in the brain where they co-express (striatum, olfactory tubercle and nucleus accumbens). Other tissues including heart, kidney, and lung also express A2aAR.
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Protein Aliases: A2a receptor; Adenosine A2 receptor; Adenosine A2a receptor; Adenosine receptor A2a; Adenosine receptor subtype A2a; ADORA2; ADORA2A; HA2aR; RDC8
Gene Aliases: A2aR; ADORA2; ADORA2A; RDC8
UniProt ID: (Human) P29274
Entrez Gene ID: (Human) 135