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Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
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Protein Aliases: big potassium channel alpha subunit; BK alpha; BK channel; BK channel alpha subunit; BKCA alpha; BKCA alpha subunit; bSlo; calcium activated potassium channel protein; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; hypothetical protein; K(VCA)alpha; KCa1.1; large conductance calcium-activated potassium channel alpha subunit; Maxi K channel; maxi-K channel alpha subunit; maxi-K channel HSLO; MaxiK; MaxiK alpha subunit; MaxiK calcium-activated potassium channel; mSlo1; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; RbSlo; slo; Slo homolog; Slo-alpha; Slo1; slowpoke; Slowpoke homolog; stretch-activated Kca channel
Gene Aliases: 5730414M22Rik; bA205K10.1; BKCA; BKTM; cSlo; hSlo; I79_002194; KCa1.1; KCNMA; KCNMA1; KCNMA1b; KCNMA1c; MaxiK; mSlo; mSLO1; RBSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
UniProt ID: (Chicken) Q8AYS8, (Human) Q12791, (Pig) O18866, (Bovine) Q28204, (Dog) Q28265, (Rabbit) Q9BG98, (Mouse) Q08460, (Rat) Q62976
Entrez Gene ID: (Chicken) 374065, (Human) 3778, (Pig) 397434, (Bovine) 282573, (Dog) 403984, (Rabbit) 100008745, (Mouse) 16531, (Chinese hamster) 100764731, (Rat) 83731
Molecular Function: ion channel
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