Percent identity with other species by BLAST analysis: Human (100%) Gorilla (94%) Gibbon (89%).
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-alanine receptor; G-protein coupled receptor TGR7; mas-related G protein-coupled MRGD; Mas-related G-protein coupled receptor member D; MAS-related GPR, member D
Gene Aliases: MRGD; MRGPRD; TGR7
UniProt ID: (Human) Q8TDS7
Entrez Gene ID: (Human) 116512