A suggested positive control is human kidney tissue lysate.
PA5-34395 can be used with blocking peptide PEP-1437.
TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.
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Protein Aliases: hTTY2; mTTY2; Protein tweety homolog 2; TTYH2; tweety family member 2; Tweety homolog 2
Gene Aliases: 1110001A03Rik; C17orf29; RGD1562969; TTYH2