|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment contains a sequence corresponding to a region within amino acids 1362 and 1636 of ROBO1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-34931 targets ROBO1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-34931 immunogen is recombinant fragment contains a sequence corresponding to a region within amino acids 1362 and 1636 of ROBO1.
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Deleted in U twenty twenty; DUTT1; H-Robo-1; Roundabout homolog 1; roundabout, axon guidance receptor, homolog 1; SAX3
Gene Aliases: DUTT1; ROBO1; SAX3
UniProt ID: (Human) Q9Y6N7
Entrez Gene ID: (Human) 6091
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor
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