Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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This antibody detects endogenous protein at a molecular weight of 31 kDa.
Purity is >95% by SDS-PAGE.
Aquaporin 12 (AQP12) is the most recently identified member of the mammalian AQP family and is specifically expressed in pancreatic acinar cells. In vitro expression studies have revealed that AQP12 is localized at intracellular sites. To determine the physiological roles of AQP12 in the pancreas, we generated knockout mice for this gene (AQP12-KO). No obvious differences were observed under normal conditions between wild-type (WT) and AQP12-KO mice in terms of growth, blood chemistry, pancreatic fluid content, or histology. However, when we induced pancreatitis through the administration of a cholecystokinin-8 (CCK-8) analog, the AQP12-KO mice showed more severe pathological damage to this organ than WT mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AQP-12; AQP-12B; aquaporin 12; aquaporin 12B; aquaporin X2; Aquaporin-12; Aquaporin-12A; Aquaporin-12B; insulin synthesis associated 3
Gene Aliases: AB084104; AQP-12; AQP12; AQP12A; AQP12B; AQPX2; INSSA3; mAQP12; RGD1562727
UniProt ID: (Human) Q8IXF9, (Human) A6NM10, (Mouse) Q8CHJ2
Entrez Gene ID: (Human) 375318, (Human) 653437, (Mouse) 208760, (Rat) 367316
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