A recommended positive control is Jurkat cell lysate.
Multiple isoforms of PROM1 are known to exist.
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: AC133; Antigen AC133; Antigen AC133 homolog; CD133; CORD12; fudenine; hematopoietic stem cell antigen; hProminin; MCDR2; MSTP061; Prominin-1; prominin-like 1; Prominin-like protein 1; PROML1; STGD4
Gene Aliases: 4932416E19Rik; AC133; CD133; CORD12; MCDR2; MSTP061; Prom; Prom-1; PROM1; PROML1; RP41; STGD4
Molecular Function: membrane traffic protein