A recommended positive control is human testis tissue lysate.
At least three isoforms are known to exist; this antibody will detect the two longest isoforms.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP4, also known as hAKAP82, is a major sperm fibrous sheath protein that localizes to the entire length of the flagellum of human sperm. It has been suggested that AKAP4 plays multiple roles in sperm motility and regulation of signal transduction pathways. AKAP4 has also been postulated to be a potential biomarker for breast cancer.
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Protein Aliases: A kinase (PRKA) anchor protein 4; A-kinase anchor protein 4; A-kinase anchor protein 82 kDa; AKAP 82; AKAP-4; AKAP4; cancer/testis antigen 99; HI; Major sperm fibrous sheath protein; PRKA4; protein kinase A anchoring protein 4; Protein kinase A-anchoring protein 4; testis-specific gene HI
Gene Aliases: AKAP 82; AKAP-4; AKAP4; AKAP82; CT99; FSC1; hAKAP82; HI; p82; PRKA4
UniProt ID: (Human) Q5JQC9
Entrez Gene ID: (Human) 8852