This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
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Protein Aliases: T2R13; Taste receptor family B member 3; Taste receptor type 2 member 13; taste receptor, family B, member 3; taste receptor, type 2, member 13; TRB3
Gene Aliases: T2R13; TAS2R13; TRB3
UniProt ID: (Human) Q9NYV9
Entrez Gene ID: (Human) 50838