This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells. Several bitter taste receptors are expressed in a single taste receptor cell.
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Protein Aliases: candidate taste receptor T2R3; T2R3; Taste receptor type 2 member 3; taste receptor, type 2, member 3
Gene Aliases: T2R3; TAS2R3
UniProt ID: (Human) Q9NYW6
Entrez Gene ID: (Human) 50831