Peptide sequence: DATLFCEPWT LNMQPAPLTS EEFKHVGLTA AVLSAHTQKE EQNYVDKFRE\r
Sequence homology: Dog: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 86%; Rat: 93%; Sheep: 86%; Zebrafish: 79%
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3; hPER3; period circadian protein 3; Period circadian protein homolog 3
Gene Aliases: FASPS3; GIG13; PER3
UniProt ID: (Human) P56645
Entrez Gene ID: (Human) 8863