Peptide sequence: RLGRLDLPRG YGETALLRAE ADFYQIRPLL DALRELEASQ GTPAPTAALL
Sequence homology: Cow: 100%; Goat: 90%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BTB/POZ domain-containing protein KCTD11; KCASH1 protein; potassium channel tetramerisation domain containing 11; potassium channel tetramerisation domain containing 11-like; Potassium channel tetramerization domain-containing protein 11; retinoic acid, EGF, and NGF upregulated; retinoic acid, EGF, NGF induced gene protein; retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domain containing 11; RING-type E3 ubiquitin transferase subunit KCTD11
Gene Aliases: AF465352; BOS_18708; C17orf36; KCASH1; KCTD11; REN; REN/KCTD11
Molecular Function: enzyme modulator