Peptide sequence: SSRDGYSSRD YREPRGFAPS PGEYTHRDYG HSSVRDDCPL RGYSDRDGYG
Sequence homology: Cow: 85%; Dog: 77%; Guinea Pig: 77%; Horse: 77%; Human: 100%; Mouse: 77%; Rabbit: 85%; Rat: 85%
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. RBMXL2 has two RRM domains that bind RNAs. RBMXL2 has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility.This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
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Protein Aliases: heterogeneous nuclear ribonucleoprotein G T; hnRNP G-T; RNA binding motif protein, X-linked-like 2; RNA-binding motif protein, X-linked-like-2; testes specific heterogenous nuclear ribonucleoprotein G T; testes-specific heterogenous nuclear ribonucleoprotein G-T; Testis-specific heterogeneous nuclear ribonucleoprotein G-T
Gene Aliases: HNRNPG-T; HNRNPGT; HNRPGT; RBMXL2
UniProt ID: (Human) O75526
Entrez Gene ID: (Human) 27288