Peptide sequence: GASNTALARW LPPVYEDGFS QPRGWNPGFL YNGFPLPPVR EVTRHVIQVS
Sequence homology: Dog: 93%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%; Yeast: 83%
Thyroid Peroxidase is a transmembrane protein of 107 kDa containing a heme prosthetic group and it is present on the apical surface of the thyroid follicular cells. It is the primary enzyme involved in thyroid hormone synthesis. Malignant thyroid tumors exhibit an anomaly in Thyroid Peroxidase resulting in lower antibody affinity. This antibody may be useful aid in the differentiation between the benign and malignant thyroid tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 1.11.1; thyroid microsomal antigen; Thyroid peroxidase; thyroperoxidase; TPO; TPXEC 188.8.131.52
Gene Aliases: MSA; TDH2A; TPO; TPX
UniProt ID: (Human) P07202
Entrez Gene ID: (Human) 7173
Molecular Function: peroxidase