Peptide sequence: SGYNAWLSYE LQPETASASI PFRVGLYTGE ISTTRALDET DAPRQRLLVL
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rat: 93%
The gene encoding PCDHA4 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. PCDHA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.
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Protein Aliases: cadherin-related neuronal receptor 1; Cadherin-related neuronal receptor 4; CNR1; CNRN1; CRNR1; KIAA0345-like 10; MGC138307; MGC142169; ortholog of mouse CNR1; PCDH-alpha-4; PCDH-ALPHA4; Protocadherin alpha 4; Protocadherin alpha-4
Gene Aliases: CNR1; CNRN1; Cnrv4; CRNR1; PCDH-ALPHA4; PCDHA4; R75250