Peptide sequence: NVCANGDCSN LEGSYMCSCH KGYTRTPDHK HCRDIDECQQ GNLCVNGQCK
Sequence homology: Cow: 92%; Dog: 92%; Guinea Pig: 83%; Horse: 86%; Human: 100%; Mouse: 83%; Rabbit: 92%; Rat: 83%
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins. The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: LanC (bacterial lantibiotic synthetase component C)-like 1; latent TGF beta binding protein; latent transforming growth factor beta binding protein 1; latent transforming growth factor binding protein 1; Latent-transforming growth factor beta-binding protein 1; LTBP-1; MGC163161; TGF-beta-1-BP-1; TGF-beta1-BP-1; Transforming growth factor beta-1-binding protein 1; Transforming growth factor beta-1-masking protein large subunit; transforming growth factor-beta (TGF-beta) masking protein large subunit
Gene Aliases: 9430031G15Rik; 9830146M04; b2b1000Clo; BOS_11420; Ltbp-1; LTBP1; Tgfb
Molecular Function: annexin calcium-binding protein calmodulin cell adhesion molecule extracellular matrix glycoprotein extracellular matrix protein extracellular matrix structural protein intracellular calcium-sensing protein signaling molecule