|Immunohistochemistry (Frozen) (IHC (F))||5-15 µg/mL|
|Western Blot (WB)||0.1 µg/mL|
|Host / Isotype||Goat / IgG|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant rat ROBO1 Lys19-Ile560|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 5% trehalose|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Reconstitute at 0.2 mg/mL in sterile PBS.
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DUTT1; Roundabout homolog 1; SAX3
Gene Aliases: Robo1
UniProt ID: (Rat) O55005
Entrez Gene ID: (Rat) 58946
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor
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