In direct ELISAs and Western blots, approximately 30% cross-reactivity with recombinant human CHIT1 is observed.\r
Reconstitute at 0.2 mg/mL in sterile PBS.
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.
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Protein Aliases: Chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 18.104.22.168; FLJ00314; MGC125322
Gene Aliases: 2300002L19Rik; Chit1
UniProt ID: (Mouse) Q9D7Q1
Entrez Gene ID: (Mouse) 71884