In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Tie-2, recombinant mouse Tie-2, and rhTie-1 is observed.\r
Reconstitute at 0.2 mg/mL in sterile PBS.
TIE2, also known as TEK tyrosine kinase, TIE2 gene is mapped to 9p21.2. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
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Protein Aliases: CD202b antigen; EC 2.7.10; EC 184.108.40.206; endothelium-specific receptor tyrosine kinase 2; TEKT1; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor Tie-2
Gene Aliases: tie-2; tie2
UniProt ID: (Zebrafish) O73791
Entrez Gene ID: (Zebrafish) 30747